San Diego .NET User Group: The San Diego .NET User Group is the premiere .NET resource in the San Diego area. Its mission is to facilitate education and knowledge exchange among developers, architects and managers with an interest in Microsoft's .NET technologies. With its SIG and Main meetings, the group hosts an estimated 60 events annually, in addition to all-day conferences. It is a world-class user group, featuring world-class events and speakers.
For more information and meeting times and locations:

San Diego .NET Developers : This group was created in 1994 by local programmers for the purpose of exchanging useful information relating to Microsoft Visual Basic and related tools and has now grown into the .NET technologies. The meetings include topics on .NET itself as well as database, software design, software management, internet, and software business issues. The group encompasses the entire process of software development and tools from a .NET-centric angle.
For more information, as well as your invitation to join: